Nanomaterials-Biological Interactions Knowledgebase
The ability to manipulate matter at the atomic scale will enable a broad range of beneficial applications in the electronics, healthcare (e.g. nanomedicine, imaging, and diagnostics), cosmetics, technologies and engineering industries. Pertinent to the development of promising nanotechnologies and to the safety of nanoscale materials in general, is a thorough understanding of nanomaterial-biological interactions. Information currently being gained in this emerging field is extremely diverse including a multitude of widely varying nanomaterials that are being/or will be tested in a broad array of animal systems and in vitro assays. Knowledge of nanomaterial-biological interactions will likely only be arrived at upon inclusion and consideration of the entire body of data produced from global efforts in this research area.
To address these needs in the nascent field of nanobiotechnology, researchers at OSU and SNNI are developing a collaborative knowledgebase of Nanomaterial-Biological Interactions (NBI). The NBI knowledgebase will serve as a repository for annotated data on nanomaterial characterization (e.g. purity, electronic and photonic properties, size, shape, charge, composition, functionalization, agglomeration state, etc.), synthesis methods, and nanomaterial-biological interactions (i.e. beneficial, benign or deleterious) defined at multiple levels of biological organization (e.g. molecular, cellular, or organismal); thus providing the framework to conduct species, route, dose and scenario extrapolations and identify key data required to predict the biological interactions of nanomaterials.
To go to the database, click here